Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6738303 | 0.91 | KCNH2 (0.49) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6736864 | 0.91 | KCNH2 (0.51) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6738449 | 0.91 | KCNH2 (0.51) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6738998 | 0.91 | KCNH2 (0.51) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6739436 | 0.90 | KCNH2 (0.50) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6742834 | 0.89 | KCNH2 (0.50) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6734797 | 0.89 | KCNH2 (0.50) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6739387 | 0.89 | KCNH2 (0.50) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7474790 | 0.88 | KCNH2 (0.47) | KCNH2KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6739920 | 0.87 | MGLL (0.50) | KCNH2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192157-A1 | BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077000-A1 | NEW BISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |