SCHEMBL7478754

SCHEMBL7478754

O=C1Cc2ccc3c(c2N1)OCO3

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 4/20 0.42
HSD17B10 Q99714 2/20 0.41
POLB P06746 1/20 0.41
MAPT P10636 1/20 0.41
NQO2 P16083 2/20 0.39
GSK3B P49841 1/20 0.37
CHRNB2 P17787 1/20 0.36
CHRNB4 P30926 1/20 0.36
CHRNA3 P32297 1/20 0.36
CHRNA7 P36544 1/20 0.36
CHRNA4 P43681 1/20 0.36
TXNRD1 Q16881 1/20 0.36
TXNRD3 Q86VQ6 1/20 0.36
TXNRD2 Q9NNW7 1/20 0.36
KDM4E B2RXH2 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35
PDK2 Q15119 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18289475 0.74 AHR (0.59) AHRPDK2CMA1EIF2AK2TDP2
SCHEMBL9835971 0.72 POLB (0.41) AHRHSD17B10POLBMAPTNQO2
SCHEMBL9739386 0.72 CYP2C19 (0.43) HSD17B10POLBMAPTNQO2GSK3B
SCHEMBL15334115 0.71 GSK3B (0.42) HSD17B10MAPTNQO2GSK3BTXNRD1
SCHEMBL24104845 0.69 CES1 (0.43) MAPTNQO2GSK3BTXNRD1TXNRD3
SCHEMBL11336504 0.68 CYP2D6 (0.45) HSD17B10NQO2CHRNB2CHRNB4CHRNA3
SCHEMBL27941934 0.67 AHR (0.44) AHRHSD17B10POLBMAPTGSK3B
SCHEMBL9834868 0.66 AHR (0.46) AHRHSD17B10POLBMAPTKDM4E
SCHEMBL8319733 0.66 CYP2D6 (0.46) HSD17B10NQO2CHRNB2CHRNB4CHRNA3
SCHEMBL12572162 0.64 AHR (0.58) AHRPDK2CMA1TDP2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1212318-A1 SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS Boehringer Ingelheim Pharma KG (DE) 2002-06-12 EP disclosed
WO-2001016130-A1 SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS BOEHRINGER INGELHEIM PHARMA KG (DE) 2001-03-08 WO disclosed
EP-0208510-B1 1-SUBSTITUTED OXINDOLE-3-CARBOXAMINES AS ANTIINFLAMMATORY AND ANALGESIC AGENTS PFIZER INC. (US) 1991-09-11 EP disclosed
US-4791129-A RHEUMATIC DISEASES; ANTIARTHRITIC AGENTS PFIZER INC. (US) 1988-12-13 US disclosed
US-4725616-A ANTIARTHRITIC AGENTS PFIZER INC. (US) 1988-02-16 US disclosed
EP-0208510-A2 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents PFIZER INC. (US) 1987-01-14 EP disclosed