Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099103 | 0.89 | CTSK (0.47) | CTSKALDH1A1MAPK1 | |
| SCHEMBL5099105 | 0.89 | CTSK (0.47) | CTSKALDH1A1MAPK1 | |
| SCHEMBL5092908 | 0.85 | CTSK (0.58) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5092898 | 0.85 | CTSK (0.58) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7207130 | 0.82 | CTSK (0.45) | CTSKCTSLCTSSCACNA1BCTSB | |
| SCHEMBL6762056 | 0.82 | CTSK (0.47) | CTSKCTSLCTSSCACNA1BCTSB | |
| SCHEMBL6762057 | 0.82 | CTSK (0.47) | CTSKCTSLCTSSCACNA1BCTSB | |
| SCHEMBL4902191 | 0.80 | CTSK (0.51) | CTSKCTSLCTSSCACNA1BKMT2A | |
| SCHEMBL7036592 | 0.80 | CTSK (0.51) | CTSKCTSLCTSSCACNA1BKMT2A | |
| SCHEMBL4686419 | 0.77 | CTSK (0.56) | CTSKALDH1A1CTSLCTSSCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |