SCHEMBL7479344

SCHEMBL7479344

Cc1onc(-c2nnc3c4ccccc4c(Cl)nn23)c1C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 3/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
SMN1; SMN2 Q16637 4/20 0.43
TSHR P16473 2/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MAPT P10636 5/20 0.41
LMNA P02545 2/20 0.41
THRB P10828 1/20 0.41
APAF1 O14727 1/20 0.40
HPGD P15428 1/20 0.40
RECQL P46063 1/20 0.40
GABRA1 P14867 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA5 P31644 1/20 0.39
GABRA3 P34903 1/20 0.39
GABRA2 P47869 1/20 0.39
TP53 P04637 2/20 0.39
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7449144 0.83 RXFP1 (0.52) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL7480128 0.79 RXFP1 (0.57) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL7453660 0.79 RXFP1 (0.48) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL7450997 0.79 RXFP1 (0.48) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL7451922 0.77 RXFP1 (0.58) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL18973197 0.76 RXFP1 (0.57) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL1258627 0.76 GABRA1 (0.58) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL31058084 0.76 GABRA1 (0.58) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1
SCHEMBL7475599 0.74 GABRA1 (0.69) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL497285 0.74 NPC1 (0.69) RXFP1L3MBTL1SMN1; SMN2TSHRNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1252143-A1 METHOD FOR PREPARING ALPHA-SULFONYL HYDROXAMIC ACID DERIVATIVES American Cyanamid Company (US) 2002-10-30 EP disclosed
EP-0986562-B1 SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME (GB) 2002-08-07 EP disclosed
US-6310203-B1 Precursor compounds to substituted 1,2,4-triazolo[3,4,-a]phathalazine GABA alpha 5 ligands MERCK SHARPE & DOHME LIMITED (GB) 2001-10-30 US disclosed
WO-2001055112-A1 METHOD FOR PREPARING ALPHA-SULFONYL HYDROXAMIC ACID DERIVATIVES AMERICAN CYANAMID COMPANY (US) 2001-08-02 WO disclosed
US-6200975-B1 FOR COGNITION ENHANCEMENT THERAPY MERCK SHARP & DOHME LIMITED (GB) 2001-03-13 US disclosed
EP-0986562-A1 SUBSTITUTED 1,2,4-TRIAZOLO 3,4-A]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LTD. (GB) 2000-03-22 EP disclosed
WO-1998050385-A1 SUBSTITUTED 1,2,4-TRIAZOLO[3,4-a]PHTHALAZINE DERIVATIVES AS GABA ALPHA 5 LIGANDS MERCK SHARP & DOHME LIMITED (GB) 1998-11-12 WO disclosed