Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TOP1 | P11387 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10828347 | 0.79 | PDK2 (0.57) | CA1CA2CA7CA9KMT2A | |
| SCHEMBL12896658 | 0.77 | RET (0.54) | CA1CA2CA7CA9RET | |
| SCHEMBL7423435 | 0.76 | CA1 (0.43) | CA1CA2CA7CA9MEN1 | |
| SCHEMBL7477188 | 0.76 | NSD2 (0.53) | CA1CA2CA7CA9MEN1 | |
| SCHEMBL29506314 | 0.74 | L3MBTL1 (0.65) | CA1CA2CA7CA9RET | |
| SCHEMBL5323040 | 0.74 | L3MBTL1 (0.65) | CA1CA2CA7CA9RET | |
| SCHEMBL2266645 | 0.70 | KMT2A (0.49) | CA1CA2CA7CA9MEN1 | |
| SCHEMBL29042890 | 0.70 | CA1 (0.45) | CA1CA2CA7CA9RET | |
| SCHEMBL18673386 | 0.69 | L3MBTL1 (0.44) | CA1CA2CA7CA9RET | |
| SCHEMBL25247154 | 0.68 | KMT2A (0.43) | CA1CA2CA7CA9KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0697405-B1 | Substituted quinoline derivatives, process for their preparation and their use | AVENTIS PHARMA GMBH (DE) | 2002-08-14 | — | — | EP | disclosed |
| EP-0579968-B1 | 4-Iminoquinolines, processes for their preparation and their use | HOECHST AG (DE) | 1999-09-01 | — | — | EP | disclosed |
| EP-0697405-A1 | Substituted quinoline derivatives, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-02-21 | — | — | EP | disclosed |
| EP-0579968-A1 | 4-Iminoquinolines, processes for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-01-26 | — | — | EP | disclosed |