Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | GPR183 | P32249 | 2/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484017 | 0.89 | ABCB11 (0.43) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7482672 | 0.85 | MEN1 (0.47) | ABCB11NPC1RAB9A | |
| SCHEMBL27554521 | 0.84 | ABCB11 (0.52) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL27531753 | 0.81 | ABCB11 (0.47) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL27554921 | 0.81 | ABCB11 (0.49) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8137639 | 0.81 | ABCB11 (0.49) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8120167 | 0.81 | ABCB11 (0.49) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7802347 | 0.80 | F10 (0.41) | ABCB11TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL7479523 | 0.80 | PTGS2 (0.55) | — | |
| SCHEMBL8134012 | 0.80 | ABCB11 (0.48) | ABCB11TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1065204-B1 | Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents and as COX-2 inhibitors | PFIZER (US) | 2002-04-10 | — | — | EP | disclosed |