Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 10/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394083 | 0.77 | PTGES (0.58) | ALOX5PTGESPTGS1 | |
| Choline SCHEMBL1393676 | 0.69 | PTGES (0.52) | ALOX5PTGESPTGS1 | |
| SCHEMBL4148109 | 0.65 | ALOX5 (0.68) | ALOX5PTGESPTGS1 | |
| SCHEMBL18768389 | 0.64 | FLT3 (0.49) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL16161638 | 0.62 | ALOX5 (0.48) | ALOX5PTGESPTGS1MEN1KMT2A | |
| SCHEMBL9458606 | 0.62 | ALOX5 (0.53) | ALOX5PTGESPTGS1MEN1KMT2A | |
| SCHEMBL9458734 | 0.61 | PTGES (0.65) | ALOX5PTGESPTGS1 | |
| SCHEMBL731363 | 0.61 | MAOB (0.71) | ALOX5PTGESMAPTALDH1A1KDM4E | |
| SCHEMBL31105656 | 0.61 | MAOB (0.71) | ALOX5PTGESMAPTALDH1A1KDM4E | |
| SCHEMBL4601674 | 0.61 | MAOB (0.58) | ALOX5MAPTALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763036-B1 | [a]-ANNELATED PYRROLE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | MERCKLE GMBH (DE) | 2002-09-11 | — | — | EP | claimed |