Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 7/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BUB1 | O43683 | 11/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7480743 | 0.82 | ALPL (0.72) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL17977834 | 0.78 | ALPL (0.70) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7491199 | 0.76 | ALPL (0.74) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7490603 | 0.74 | ALPL (0.64) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7490668 | 0.74 | ALPL (0.65) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7482110 | 0.74 | ALPL (0.58) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7484888 | 0.73 | ROCK2 (0.42) | ALPLHSD17B10ALDH1A1HPGDKDM4E | |
| SCHEMBL7684925 | 0.73 | BUB1 (0.65) | BUB1 | |
| SCHEMBL17372220 | 0.72 | BUB1 (0.66) | BUB1 | |
| SCHEMBL460286 | 0.72 | HSD17B10 (0.63) | ALPLHSD17B10ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |