Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 8/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.52 |
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7759237 | 0.99 | AURKA (0.54) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6587278 | 0.91 | AURKA (0.54) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL7485013 | 0.91 | AURKA (0.52) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6587512 | 0.91 | AURKA (0.54) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6587264 | 0.90 | AURKA (0.55) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6589042 | 0.84 | AURKA (0.56) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6591285 | 0.83 | AURKA (0.51) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6586056 | 0.82 | AURKA (0.59) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6586837 | 0.82 | AURKA (0.56) | AURKAAURKBKDRDGAT1KCNH2 | |
| SCHEMBL6588365 | 0.82 | AURKA (0.54) | AURKAAURKBKDRDGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2001082877-A2 | USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS | BASF AKTIENGESELLSCHAFT (DE) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000068206-A1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-16 | — | — | WO | disclosed |