Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 17/20 | 0.47 |
| ▸ | HTR1B | P28222 | 15/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR1F | P30939 | 2/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481110 | 0.91 | HTR1D (0.51) | HTR1DHTR1BHTR1AHTR1FCCR2 | |
| SCHEMBL7484773 | 0.85 | HTR1D (0.49) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7475411 | 0.83 | HTR1D (0.50) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7481645 | 0.83 | HTR1D (0.51) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7481588 | 0.81 | NOS3 (0.47) | — | |
| SCHEMBL7481902 | 0.81 | HTR1D (0.48) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7490145 | 0.81 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR1FAPP | |
| SCHEMBL7483667 | 0.79 | UBE2M (0.48) | HTR1DHTR1BHTR1AHTR1FCCR2 | |
| SCHEMBL7485759 | 0.79 | HTR1D (0.47) | HTR1DHTR1BHTR1AHTR1FCCR2 | |
| SCHEMBL8383553 | 0.78 | SLC6A4 (0.45) | HTR1DHTR1BHTR1AHTR1FAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733628-B9 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0733628-B1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5962474-A | ANALGESICS; HEADACHES | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5708008-A | TREATMENT OF MIGRAINE | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0733628-A1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists | ELI LILLY AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |