Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591601 | 1.00 | RIPK1 (0.55) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL6199357 | 0.88 | RIPK1 (0.53) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL130221 | 0.86 | RIPK1 (0.52) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL3081755 | 0.85 | RIPK1 (0.64) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL5185803 | 0.85 | RIPK1 (0.64) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL11234621 | 0.85 | RIPK1 (0.50) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL11828179 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL8710104 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL29860819 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 | |
| SCHEMBL4837244 | 0.82 | RIPK1 (0.61) | RIPK1LMNAKDM4EL3MBTL1AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1111156-C | Alpha, alpha'-diaminoalcohol and preparation process thereof | HOFFMANN LA ROCHE (CH) | 2003-06-11 | — | — | CN | claimed |
| CN-1275563-A | Alpha, alpha'-diaminoalcohol and preparation process thereof | HOFFMANN LA ROCHE (CH) | 2000-12-06 | — | — | CN | claimed |
| CN-1099387-A | Process for the preparation of beta-aminoalcohols | HOFFMANN LA ROCHE (CH) | 1995-03-01 | — | — | CN | claimed |
| CN-1052482-A | AMINO ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1991-06-26 | — | — | CN | claimed |
| CN-1244575-C | Sulfonylalkylamido hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 2006-03-08 | — | — | CN | disclosed |
| CN-1204144-C | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 2005-06-01 | — | — | CN | disclosed |
| CN-1178954-C | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G��D��ɪ����˾ | 2004-12-08 | — | — | CN | disclosed |
| CN-1530372-A | Inhibitor of hecterocyclic oxoaminoethylol aminosulfonic amine reverse transcripted virus protenase | G.D.ɪ����˾ | 2004-09-22 | — | — | CN | disclosed |
| CN-1149223-C | Heterocyclic carbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G��D��ɪ����˾ | 2004-05-12 | — | — | CN | disclosed |
| CN-1476436-A | Novel compounds for use as HIV protease inhibitors | - | 2004-02-18 | — | — | CN | disclosed |
| CN-1066329-C | Preparation of drug composition | HOFFMANN LA ROCHE (CH) | 2001-05-30 | — | — | CN | disclosed |
| CN-1196732-A | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 1998-10-21 | — | — | CN | disclosed |
| CN-1186499-A | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 1998-07-01 | — | — | CN | disclosed |
| CN-1183767-A | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 1998-06-03 | — | — | CN | disclosed |
| CN-1183102-A | Heterocyclic carbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | SEARLE & CO (US) | 1998-05-27 | — | — | CN | disclosed |
| EP-0813543-A1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-12-29 | — | — | EP | disclosed |
| WO-1997018205-A1 | SUBSTITUTED SULFONYLALKANOYLAMINO HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1997-05-22 | — | — | WO | disclosed |
| WO-1996028464-A1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | G.D. SEARLE & CO. (US) | 1996-09-19 | — | — | WO | disclosed |
| EP-0666841-A1 | SUCCINOYLAMINO HYDROXYETHYLAMINO SULFAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS. | SEARLE & CO (US) | 1995-08-16 | — | — | EP | disclosed |
| CN-1052482-A | AMINO ACID DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1991-06-26 | — | — | CN | disclosed |