Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478621 | 0.71 | ELANE (0.34) | ELANENPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL7330116 | 0.67 | KMT2A (0.35) | NPC1RAB9ASMN1; SMN2CYP2C19FFAR1 | |
| SCHEMBL7480783 | 0.63 | POLB (0.32) | NPC1SMN1; SMN2GAACYP2C19DAO | |
| SCHEMBL7426545 | 0.63 | ELANE (0.43) | ELANEATMGAAKDM4EPKM | |
| SCHEMBL7331500 | 0.62 | ALDH1A1 (0.36) | ELANENPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7330348 | 0.62 | ELANE (0.50) | ELANENPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7331991 | 0.61 | ELANE (0.38) | ELANENPC1RAB9ASMN1; SMN2APLNR | |
| SCHEMBL9085819 | 0.60 | GAA (0.41) | GAACYP2C19HDAC6 | |
| SCHEMBL7288265 | 0.59 | ELANE (0.66) | ELANE | |
| SCHEMBL7290427 | 0.59 | ELANE (0.64) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801648-A4 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0801648-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| WO-1996016951-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |