SCHEMBL7480783

SCHEMBL7480783

CCCC(C)C1NS(=O)(=O)N(CSc2ccccc2)C1=O

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
DAO P14920 1/20 0.32
MTNR1A P48039 3/20 0.32
MTNR1B P49286 3/20 0.32
PNKP Q96T60 1/20 0.31
FKBP1A P62942 1/20 0.31
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
KMT2A Q03164 1/20 0.30
LMNA P02545 1/20 0.30
STAT3 P40763 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7331500 0.86 ALDH1A1 (0.36) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7330116 0.78 KMT2A (0.35) ALDH1A1CYP1A2CYP3A4MAPTCYP2C9
SCHEMBL9085819 0.71 GAA (0.41) POLBALDH1A1CYP1A2CYP3A4GAA
SCHEMBL7328442 0.66 ALDH1A1 (0.51) POLBALDH1A1CYP1A2CYP3A4GAA
SCHEMBL7332491 0.66 MTNR1A (0.35) POLBALDH1A1CYP1A2CYP2C19DAO
SCHEMBL7330348 0.66 ELANE (0.50) POLBALDH1A1CYP1A2CYP3A4MAPT
SCHEMBL7329575 0.66 ELANE (0.38) POLBALDH1A1MTNR1AMTNR1BFKBP1A
SCHEMBL7331991 0.64 ELANE (0.38) ALDH1A1CYP1A2CYP3A4MAPTCYP2C9
SCHEMBL7480787 0.63 ELANE (0.36) GAACYP2C19DAONPC1SMN1; SMN2
SCHEMBL7423743 0.60 GFER (0.38) CYP1A2CYP2C9CYP2C19MEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0801648-A4 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP INC (US) 1998-01-28 EP disclosed
EP-0801648-A1 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1997-10-22 EP disclosed
WO-1996016951-A1 SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF SANOFI WINTHROP, INC. (US) 1996-06-06 WO disclosed