Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482899 | 0.78 | HPGD (0.48) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL7484505 | 0.76 | NR1H2 (0.46) | ALDH1A1NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL7482166 | 0.71 | DCUN1D1 (0.48) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL7425395 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL7434319 | 0.70 | GRK6 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7486751 | 0.70 | ALOX5AP (0.38) | ALDH1A1MAPTPOLB | |
| SCHEMBL7487218 | 0.69 | SMN1; SMN2 (0.51) | NPC1SMN1; SMN2LMNAMAPTHTT | |
| SCHEMBL7482611 | 0.69 | PSIP1 (0.41) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL7480824 | 0.65 | TDP1 (0.35) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 | |
| SCHEMBL2069838 | 0.64 | NPC1 (0.52) | ALDH1A1NPC1RAB9ATDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1379777-A | Amino-triazolopyridine derivatives | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |