Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | APLNR | P35414 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7484993 | 0.79 | ALDH1A1 (0.42) | TDP1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL7490899 | 0.77 | HDAC1 (0.45) | TDP1NPC1RAB9APSIP1ALDH1A1 | |
| SCHEMBL7481950 | 0.73 | ALDH1A1 (0.38) | NPC1RAB9APSIP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7487578 | 0.72 | HDAC1 (0.48) | TDP1NPC1RAB9APSIP1POLB | |
| SCHEMBL7482230 | 0.71 | HDAC1 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2AUSP2 | |
| SCHEMBL7486763 | 0.71 | NSD2 (0.39) | HSD11B1 | |
| SCHEMBL7487226 | 0.70 | PTGS2 (0.40) | ALDH1A1SMN1; SMN2HSD11B1L3MBTL1 | |
| SCHEMBL7482618 | 0.70 | PSIP1 (0.41) | NPC1RAB9APSIP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7480819 | 0.65 | ALDH1A1 (0.42) | TDP1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL347966 | 0.60 | MAOB (0.53) | TDP1NPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |