Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.37 |
| ▸ | WNT3A | P56704 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26095095 | 0.77 | MAPT (0.39) | XDHSLC22A12MAPTPOLBKDM4E | |
| SCHEMBL30950146 | 0.77 | MAPT (0.39) | XDHSLC22A12MAPTPOLBKDM4E | |
| SCHEMBL7488343 | 0.74 | KDM4E (0.38) | XDHSLC22A12MAPTPOLBKDM4E | |
| SCHEMBL7482318 | 0.73 | MAOB (0.36) | XDHSLC22A12CYP3A4 | |
| SCHEMBL31305973 | 0.73 | MAOB (0.36) | XDHSLC22A12CYP3A4 | |
| SCHEMBL29433461 | 0.72 | MAPT (0.42) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL5988003 | 0.72 | ACVR1 (0.41) | XDHMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL12253686 | 0.69 | PKM (0.57) | PKMMAPTPOLBKDM4EHSD17B10 | |
| SCHEMBL9574305 | 0.68 | PKM (1.00) | PKMMAPTPOLBKDM4EHTT | |
| SCHEMBL1066340 | 0.68 | GAA (0.43) | PKMMAPTPOLBKDM4ECTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783499-B1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-5935972-A | Benzofuran derivatives as tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| EP-0783499-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1995006645-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-09 | — | — | WO | disclosed |