Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 12/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348787 | 0.78 | ERN1 (0.41) | KDM4EPOLBMAPTHSD17B10ERN1 | |
| SCHEMBL26095095 | 0.77 | MAPT (0.39) | KDM4EPOLBMAPTHSD17B10CYP2A6 | |
| SCHEMBL30950146 | 0.77 | MAPT (0.39) | KDM4EPOLBMAPTHSD17B10CYP2A6 | |
| SCHEMBL24339599 | 0.76 | ERN1 (0.44) | KDM4EMAPTERN1CYP2A6ALDH1A1 | |
| SCHEMBL7480987 | 0.74 | PKM (0.51) | KDM4EPOLBMAPTHSD17B10CYP2A6 | |
| SCHEMBL31141575 | 0.74 | CYP2A6 (0.52) | KDM4EPOLBERN1CYP2A6ALDH1A1 | |
| SCHEMBL4148963 | 0.73 | ERN1 (0.48) | MAPTERN1CYP2A6CYP3A4 | |
| SCHEMBL7492866 | 0.72 | CDK1 (0.40) | ERN1CYP2A6ALDH1A1ABCB1CYP3A4 | |
| SCHEMBL4988758 | 0.72 | ERN1 (0.53) | KDM4EMAPTHSD17B10ERN1CYP2A6 | |
| SCHEMBL29433461 | 0.72 | MAPT (0.42) | POLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783499-B1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-5935972-A | Benzofuran derivatives as tachykinin antagonists | GLAXO GROUP LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| EP-0783499-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1997-07-16 | — | — | EP | disclosed |
| WO-1995006645-A1 | BENZOFURAN DERIVATIVES AS TACHYKININ ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1995-03-09 | — | — | WO | disclosed |