Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 17/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595112 | 0.91 | NR1H2 (0.41) | NR1H2NR1H3EED | |
| SCHEMBL7593155 | 0.85 | AAK1 (0.38) | AAK1NR1H2NR1H3 | |
| SCHEMBL7967420 | 0.81 | BRD4 (0.46) | NR1H2 | |
| SCHEMBL7459831 | 0.80 | AAK1 (0.38) | AAK1NR1H2NR1H3GBA1 | |
| SCHEMBL7475885 | 0.76 | CHRM2 (0.37) | NR1H2EED | |
| SCHEMBL7481176 | 0.74 | CKS1B (0.45) | NR1H2NR1H3 | |
| SCHEMBL7016266 | 0.74 | NR1H2 (0.46) | NR1H2NR1H3 | |
| SCHEMBL19057816 | 0.73 | METAP2 (0.44) | AAK1GBA1 | |
| SCHEMBL3339614 | 0.68 | HRH3 (0.61) | AAK1 | |
| SCHEMBL20884885 | 0.68 | AAK1 (0.44) | AAK1GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0946519-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998024771-A1 | BENZAMIDE DERIVATIVES HAVING A VASOPRESSIN ANTAGONISTIC ACTIVITY | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-11 | — | — | WO | disclosed |