Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585158 | 0.86 | NR1H2 (0.45) | NR1H2HSP90AA1HSP90AB1NR1H3CA12 | |
| SCHEMBL6581361 | 0.84 | NR1H2 (0.39) | NR1H2HSP90AA1HSP90AB1NR1H3CA12 | |
| SCHEMBL21083012 | 0.83 | NR1H2 (0.43) | NR1H2HSP90AA1HSP90AB1NR1H3CA12 | |
| SCHEMBL20494743 | 0.82 | NR1H2 (0.45) | NR1H2NR1H3CA12CA9L3MBTL1 | |
| SCHEMBL7420401 | 0.80 | FBP1 (0.41) | FBP1PARP1 | |
| SCHEMBL7484481 | 0.80 | DCTPP1 (0.47) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL2858266 | 0.78 | HSP90AA1 (0.40) | NR1H2HSP90AA1HSP90AB1L3MBTL1BCHE | |
| SCHEMBL133464 | 0.77 | ALDH1A1 (0.57) | NR1H2L3MBTL1BCHE | |
| SCHEMBL7595112 | 0.76 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL7967420 | 0.74 | BRD4 (0.46) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1051415-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037637-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-29 | — | — | WO | disclosed |