Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.57 |
| ▸ | HTR1B | P28222 | 16/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | HTR1F | P30939 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039777 | 0.86 | HTR1D (0.55) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7488092 | 0.86 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7484678 | 0.85 | HTR1D (0.73) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7487625 | 0.84 | HTR1D (0.72) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL7481600 | 0.83 | HTR1D (0.58) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7480617 | 0.83 | CCR2 (0.61) | HTR1DHTR1BCHRM2DRD2 | |
| SCHEMBL7481815 | 0.83 | HTR1D (0.76) | HTR1DHTR1BHTR1AHTR1FHTR6 | |
| SCHEMBL7474419 | 0.82 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL7483816 | 0.82 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR1FCHRM2 | |
| SCHEMBL8547948 | 0.82 | DRD2 (0.56) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733628-B9 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-0733628-B1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1H-indoles: 5-HT1F agonists | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5962474-A | ANALGESICS; HEADACHES | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1996029075-A1 | 5-SUBSTITUTED-3-(1,2,3,6-TETRAHYDROPYRIDIN-4-YL)- AND 3-(PIPERIDIN-4-YL)-1H-INDOLES: NEW 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1996-09-26 | — | — | WO | disclosed |
| EP-0733628-A1 | 5-Substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists | ELI LILLY AND COMPANY (US) | 1996-09-25 | — | — | EP | disclosed |