Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640389 | 0.82 | SLC6A4 (0.65) | SLC6A4DRD2HTR2CHTR1AHTR6 | |
| SCHEMBL7484417 | 0.82 | SLC6A4 (0.53) | SLC6A4HTR1ATDO2 | |
| SCHEMBL7483841 | 0.79 | SLC6A4 (0.67) | SLC6A4HTR6SLC6A2SLC6A3 | |
| SCHEMBL31060978 | 0.77 | SLC6A4 (1.00) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL9703865 | 0.76 | SLC6A4 (0.60) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL14406107 | 0.72 | SLC6A4 (0.55) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| Hydrochloric Acid SCHEMBL11327351 | 0.71 | KDM4E (0.71) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL11314586 | 0.71 | KDM4E (0.71) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| Ethylene SCHEMBL7481976 | 0.71 | DRD2 (0.57) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL6296691 | 0.70 | DRD2 (0.60) | SLC6A4KDM4EALOX15HSD17B10DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |