Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 7/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522501 | 0.77 | CDK9 (0.47) | KDM4EALDH1A1MAPTL3MBTL1RAB9A | |
| SCHEMBL2522495 | 0.77 | CDK9 (0.47) | KDM4EALDH1A1MAPTL3MBTL1RAB9A | |
| SCHEMBL7481973 | 0.76 | SLC6A4 (0.62) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL19746393 | 0.75 | NPC1 (0.46) | ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL31060978 | 0.75 | SLC6A4 (1.00) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL10984508 | 0.74 | HTR2A (0.54) | KDM4EALDH1A1HTR2CHTR6HTR2A | |
| SCHEMBL1762824 | 0.73 | CDK9 (0.39) | SLC6A4HTR1AHTR1DHTR1E | |
| SCHEMBL18324889 | 0.73 | LMNA (0.58) | SLC6A4KDM4EALOX15HSD17B10DRD2 | |
| SCHEMBL9703857 | 0.71 | CDK9 (0.49) | KDM4EHSD17B10MAPTNPC1RAB9A | |
| SCHEMBL28097296 | 0.71 | LMNA (0.64) | SLC6A4KDM4EALOX15HSD17B10DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992012977-A1 | SUBSTITUTED INDOLES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-08-06 | — | — | WO | disclosed |
| US-5124332-A | Dopaminergic agents, hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1992-06-23 | — | — | US | disclosed |