Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 3/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747735 | 0.77 | CYP11B2 (0.54) | CYP11B2CYP11B1 | |
| SCHEMBL28022369 | 0.66 | ESR2 (0.48) | DGAT1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28637595 | 0.66 | ESR2 (0.54) | CNR2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL21518742 | 0.64 | AKT1 (0.33) | CYP11B2AKT1AKT2 | |
| SCHEMBL21518712 | 0.64 | CYP11B1 (0.39) | CYP11B2CYP11B1 | |
| SCHEMBL27884103 | 0.63 | CYP11B1 (0.32) | CYP11B2CYP11B1 | |
| SCHEMBL30550569 | 0.63 | ESR2 (0.44) | CNR2CYP11B2CYP11B1DGAT1CNR1 | |
| SCHEMBL28637596 | 0.61 | AKT1 (0.41) | AKT1AKT2 | |
| SCHEMBL3237062 | 0.61 | TSHR (0.46) | — | |
| SCHEMBL18189534 | 0.60 | PGR (0.56) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2429995-A1 | ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS | Novartis AG (CH) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010130796-A1 | ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS | NOVARTIS AG (CH) | 2010-11-18 | — | — | WO | disclosed |