SCHEMBL7483528

SCHEMBL7483528

O=C(/C=C/c1ccccc1Cl)Nc1nnc(NCCCN2CCCC2=O)s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB2 P05107 6/20 0.51
ICAM1 P05362 6/20 0.51
ITGAL P20701 6/20 0.51
MAPT P10636 3/20 0.44
HPGD P15428 1/20 0.44
RAB9A P51151 4/20 0.44
RXFP1 Q9HBX9 2/20 0.44
NPC1 O15118 2/20 0.43
MAOB P27338 1/20 0.43
KMT2A Q03164 6/20 0.42
MEN1 O00255 3/20 0.42
POLB P06746 1/20 0.42
GAA P10253 1/20 0.42
GPR55 Q9Y2T6 1/20 0.42
CYP3A4 P08684 3/20 0.42
CYP2C19 P33261 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7483535 1.00 ITGB2 (0.51) ITGB2ICAM1ITGALMAPTHPGD
SCHEMBL7480234 0.87 HDAC1 (0.46) ITGB2ICAM1ITGALMAPTRAB9A
SCHEMBL7480244 0.87 HDAC1 (0.46) ITGB2ICAM1ITGALMAPTRAB9A
SCHEMBL7485286 0.83 MAPT (0.51) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7485298 0.83 MAPT (0.51) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7485346 0.82 CYP3A4 (0.53) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7484285 0.82 CYP3A4 (0.53) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7482925 0.79 MAPT (0.60) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7492399 0.79 MAPT (0.60) MAPTHPGDRAB9ANPC1MAOB
SCHEMBL7483102 0.79 ITGB2 (0.51) ITGB2ICAM1ITGALMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064273-B1 1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS UPJOHN CO (US) 2002-12-18 EP claimed
US-6150385-A VIRICIDE WITH ACTIVITY AGAINST CYTOMEGALO VIRUS (CMV), HERPES VIRUS INCLUDING VARICELLA ZOSTER VIRUS, THE EPSTEIN-BARR VIRUS, THE HERPES SIMPLEX VIRUS, AND THE HUMAN HERPES VIRUS TYPE 8 (HHV-8) PHARMACIA & UPJOHN COMPANY (US) 2000-11-21 US claimed
EP-1064273-B1 1,3,4-THIADIAZOLES USEFUL FOR THE TREATMENT OF CMV INFECTIONS UPJOHN CO (US) 2002-12-18 EP disclosed