SCHEMBL7484435

SCHEMBL7484435

CN(CCc1ccccn1)c1nsc2nc3ccccc3n12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.38
POLB P06746 3/20 0.38
CYP1A2 P05177 2/20 0.38
CYP3A4 P08684 2/20 0.38
CYP2D6 P10635 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
KDM4E B2RXH2 8/20 0.38
ALDH1A1 P00352 6/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
GAA P10253 2/20 0.38
HSD11B1 P28845 1/20 0.38
HIF1A Q16665 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
CACNA2D1 P54289 1/20 0.38
NPSR1 Q6W5P4 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
HTT P42858 1/20 0.37
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7473543 0.80 SMN1; SMN2 (0.39) POLBCYP2D6CYP2C19KDM4EALDH1A1
SCHEMBL7476293 0.76 HSD17B10 (0.43) TSHRPOLBCYP1A2CYP3A4CYP2C9
SCHEMBL7473547 0.71 ALDH1A1 (0.58) TSHRKDM4EALDH1A1MEN1KMT2A
SCHEMBL7473909 0.67 CTSD (0.47) TSHRPOLBKDM4EALDH1A1MEN1
SCHEMBL7481115 0.67 KDM4E (0.40) POLBKDM4EALDH1A1MEN1KMT2A
SCHEMBL7481507 0.66 KDM4E (0.53) TSHRKDM4EALDH1A1MEN1KMT2A
SCHEMBL8044065 0.66 HSD17B10 (0.47) TSHRPOLBCYP1A2CYP2C9CYP2C19
SCHEMBL1392850 0.66 POLB (0.63) TSHRPOLBCYP1A2CYP3A4CYP2D6
SCHEMBL3932328 0.66 CYP1A2 (0.59) TSHRPOLBCYP1A2CYP3A4CYP2D6
SCHEMBL7476136 0.65 KMT2A (0.41) TSHRPOLBKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6093738-A IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT KARIMIAN KHASHAYAR (CA) 2000-07-25 US claimed
CN-1216527-A Method for scavenging mercaptan APOTEX INC (CA) 1999-05-12 CN claimed
EP-0883622-A1 PROTON PUMP INHIBITOR APOTEX INC. (CA) 1998-12-16 EP claimed
EP-0883606-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1998-12-16 EP claimed
WO-1997031923-A1 PROTON PUMP INHIBITOR APOTEX INC. (CA) 1997-09-04 WO claimed
WO-1997031893-A1 PROCESS FOR SCAVENGING THIOLS APOTEX INC. (CA) 1997-09-04 WO claimed
EP-0883622-B1 PROTON PUMP INHIBITOR APOTEX INC (CA) 2002-05-15 EP disclosed
US-6114537-A 1,2,4-THIADIAZOLE COMPOUND IS USEFUL FOR TRAPPING THIOL COMPOUNDS AND SELECTIVELY CHANGING THIOLS TO DISULFIDE COMPOUNDS APOTEX INC. (CA) 2000-09-05 US disclosed
US-6093738-A IMIDAZO(1,2-D)-THIADIAZOLE COMPOUNDS; PEPTIC ULCER TREATMENT KARIMIAN KHASHAYAR (CA) 2000-07-25 US disclosed