Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 17/20 | 0.71 |
| ▸ | CASP7 | P55210 | 11/20 | 0.61 |
| ▸ | CASP1 | P29466 | 6/20 | 0.61 |
| ▸ | CASP9 | P55211 | 3/20 | 0.61 |
| ▸ | CASP2 | P42575 | 3/20 | 0.61 |
| ▸ | CASP6 | P55212 | 3/20 | 0.61 |
| ▸ | CASP4 | P49662 | 2/20 | 0.61 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.61 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597670 | 0.90 | CASP3 (0.61) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL1092156 | 0.83 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL1092160 | 0.83 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535570 | 0.83 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535574 | 0.83 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL5336634 | 0.82 | CASP3 (0.76) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535370 | 0.81 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535374 | 0.81 | CASP3 (1.00) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535351 | 0.80 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP2 | |
| SCHEMBL6535352 | 0.80 | CASP3 (0.68) | CASP3CASP7CASP1CASP9CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403792-B1 | INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | claimed |
| EP-1001933-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6403792-B1 | INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-1001933-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006367-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |