Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 14/20 | 0.68 |
| ▸ | CASP7 | P55210 | 8/20 | 0.67 |
| ▸ | CASP9 | P55211 | 4/20 | 0.67 |
| ▸ | CASP1 | P29466 | 4/20 | 0.67 |
| ▸ | CASP2 | P42575 | 3/20 | 0.67 |
| ▸ | CASP6 | P55212 | 3/20 | 0.67 |
| ▸ | CASP4 | P49662 | 2/20 | 0.67 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535351 | 1.00 | CASP3 (0.68) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL6535574 | 0.85 | CASP3 (0.76) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL6535570 | 0.85 | CASP3 (0.76) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL1092156 | 0.81 | CASP3 (1.00) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL1092160 | 0.81 | CASP3 (1.00) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL2709244 | 0.80 | BRD4 (0.71) | BRD4HCRTR1HCRTR2LMNAGAA | |
| SCHEMBL6535653 | 0.80 | CASP3 (1.00) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL6535700 | 0.80 | CASP3 (1.00) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL6535651 | 0.80 | CASP3 (1.00) | CASP3CASP7CASP9CASP1CASP2 | |
| SCHEMBL6536689 | 0.80 | CASP3 (0.64) | CASP3CASP7CASP9CASP1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001933-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | EP | claimed |
| EP-1001933-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | claimed |
| WO-1999006367-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | claimed |
| EP-1242081-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-07-21 | — | — | EP | disclosed |
| EP-1001933-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1242081-A1 | CASPASES AND APOPTOSIS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022966-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-05 | — | — | WO | disclosed |
| EP-1001933-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999006367-A1 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-11 | — | — | WO | disclosed |