Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 18/20 | 0.55 |
| ▸ | NOS1 | P29475 | 18/20 | 0.55 |
| ▸ | NOS2 | P35228 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482097 | 0.86 | NOS3 (0.71) | NOS3NOS1NOS2 | |
| Hydrochloric Acid SCHEMBL7481311 | 0.85 | NOS3 (0.69) | NOS3NOS1NOS2 | |
| SCHEMBL7482632 | 0.84 | NOS3 (0.58) | NOS3NOS1NOS2KCNH2 | |
| SCHEMBL7817443 | 0.83 | NOS3 (0.76) | NOS3NOS1NOS2KCNH2 | |
| Hydrochloric Acid SCHEMBL7487524 | 0.83 | NOS3 (0.57) | NOS3NOS1NOS2KCNH2 | |
| SCHEMBL7480138 | 0.82 | NOS3 (0.58) | NOS3NOS1NOS2KCNH2 | |
| SCHEMBL7484159 | 0.76 | ALDH1A1 (0.44) | NOS3NOS1NOS2 | |
| SCHEMBL7482742 | 0.75 | NOS3 (0.68) | NOS3NOS1NOS2KCNH2 | |
| Hydrochloric Acid SCHEMBL7555462 | 0.74 | NOS3 (0.67) | NOS3NOS1NOS2KCNH2 | |
| Hydrochloric Acid SCHEMBL7483122 | 0.74 | NOS3 (0.67) | NOS3NOS1NOS2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489322-B1 | BENZOXAZEPINES AS SELECTIVE INHIBITORS OF THE NEURONAL ISOFORM OF NITRIC OXIDE SYNTHASE FOR TREATMENT OF NEURODEGENERATIVE DISEASE | ASTRAZENECA AB (SE) | 2002-12-03 | — | — | US | claimed |
| EP-0983268-B1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | claimed |
| EP-0983268-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 2000-03-08 | — | — | EP | claimed |
| WO-1998050382-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1998-11-12 | — | — | WO | claimed |
| US-6489322-B1 | BENZOXAZEPINES AS SELECTIVE INHIBITORS OF THE NEURONAL ISOFORM OF NITRIC OXIDE SYNTHASE FOR TREATMENT OF NEURODEGENERATIVE DISEASE | ASTRAZENECA AB (SE) | 2002-12-03 | — | — | US | disclosed |
| EP-0983268-B1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| EP-0983268-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050382-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1998-11-12 | — | — | WO | disclosed |