Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28752 | 0.86 | ALDH1A1 (0.66) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| Bromide SCHEMBL27304432 | 0.85 | ALDH1A1 (0.64) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL5204102 | 0.85 | ALDH1A1 (0.64) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL7663518 | 0.84 | MAPK1 (0.66) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL27080814 | 0.83 | SMN1; SMN2 (0.73) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL4748498 | 0.77 | ALDH1A1 (0.87) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL61103 | 0.77 | ALDH1A1 (0.87) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL16026437 | 0.75 | ALDH1A1 (0.83) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL14251777 | 0.73 | CHRNB2 (0.56) | SMN1; SMN2KDM4EPKMALDH1A1HTT | |
| SCHEMBL28325613 | 0.72 | MAPT (0.49) | SMN1; SMN2PKMALDH1A1HTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218384-A4 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2002-11-20 | — | — | EP | disclosed |
| EP-1218384-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001023392-A1 | TETRACYCLIC BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-04-05 | — | — | WO | disclosed |