Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | OGA | O60502 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950203 | 0.80 | KDM4E (0.42) | KDM4EGAAMAPTNPC1LMNA | |
| SCHEMBL18252836 | 0.78 | CHRM2 (0.44) | RIPK1OGAPKMPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL7481044 | 0.78 | KDM4E (0.45) | KDM4EGAAMAPTNPC1LMNA | |
| SCHEMBL9942876 | 0.78 | HRH3 (0.41) | RIPK1LMNASMN1; SMN2OGAPIK3CA | |
| SCHEMBL7479469 | 0.76 | PIK3CD (0.42) | KDM4EGAAMAPTNPC1LMNA | |
| SCHEMBL24616867 | 0.74 | HSD17B3 (0.42) | KDM4EMAPTLMNAOGA | |
| SCHEMBL1950813 | 0.74 | HRH3 (0.48) | KDM4EGAAMAPTLMNASMN1; SMN2 | |
| SCHEMBL30534578 | 0.74 | HRH3 (0.48) | KDM4EGAAMAPTLMNASMN1; SMN2 | |
| SCHEMBL23774907 | 0.74 | RIPK1 (0.40) | GAAMAPTRIPK1LMNACHRNA7 | |
| SCHEMBL3353090 | 0.74 | HTR4 (0.33) | KDM4EGAAMAPTRIPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6489322-B1 | BENZOXAZEPINES AS SELECTIVE INHIBITORS OF THE NEURONAL ISOFORM OF NITRIC OXIDE SYNTHASE FOR TREATMENT OF NEURODEGENERATIVE DISEASE | ASTRAZENECA AB (SE) | 2002-12-03 | — | — | US | disclosed |
| EP-0983268-B1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| EP-0983268-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Astra Aktiebolag (SE) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998050382-A1 | AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE | ASTRA AKTIEBOLAG (SE) | 1998-11-12 | — | — | WO | disclosed |