Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705907 | 0.84 | ADORA2A (0.56) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7711617 | 0.80 | ADORA2A (0.44) | ADORA2AALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL7430360 | 0.78 | ADORA2A (0.56) | ADORA2A | |
| SCHEMBL7535250 | 0.77 | ADORA2A (0.42) | ADORA2A | |
| SCHEMBL7427474 | 0.76 | SMN1; SMN2 (0.47) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7491116 | 0.76 | ALDH1A1 (0.39) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7711750 | 0.73 | ADORA2A (0.57) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7711685 | 0.73 | ADORA2A (0.57) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7709236 | 0.72 | ALDH1A1 (0.48) | ADORA2AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL7432234 | 0.72 | ADORA2A (0.56) | ADORA2AALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214322-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-19 | — | — | EP | disclosed |
| US-6355653-B1 | DRUG AND CARRIER FOR ANTIALLERGENS, BRAIN DISORDERS AND NEUROTRANSMITTERS | HOFFMANN-LA ROCHE INC. | 2002-03-12 | — | — | US | disclosed |
| WO-2001017999-A2 | AMINO-TRIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-15 | — | — | WO | disclosed |