Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | HTR2B | P41595 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848345 | 0.82 | EGFR (0.44) | HTR2AHTR2CHTR2BTDP1L3MBTL1 | |
| SCHEMBL7478500 | 0.82 | HTR2A (0.44) | HTR2AHTR2CHTR2BTDP1L3MBTL1 | |
| SCHEMBL7486685 | 0.81 | TDP1 (0.50) | HTR2AKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL7478080 | 0.81 | KDM4E (0.52) | HTR2AKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL3799717 | 0.80 | CYP3A4 (0.61) | HTR2AHTR2CHTR2BKDM4EATM | |
| SCHEMBL1332634 | 0.79 | CYP3A4 (0.48) | HTR2AHTR2CHTR2BKDM4ETDP1 | |
| SCHEMBL16173474 | 0.76 | HTR2A (0.46) | HTR2ATDP1L3MBTL1RET | |
| SCHEMBL25517569 | 0.75 | L3MBTL1 (0.65) | KDM4ETDP1L3MBTL1 | |
| SCHEMBL19461974 | 0.74 | HTR2A (0.45) | HTR2ATDP1L3MBTL1PRSS1 | |
| SCHEMBL12372067 | 0.73 | HTR2A (0.47) | HTR2AHTR2CHTR2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |