Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901789 | 0.80 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL14862503 | 0.76 | CA1 (0.44) | IDO1TDO2ALDH1A1CHRM2CHRM4 | |
| SCHEMBL1494144 | 0.73 | CA1 (0.41) | IDO1TDO2ALDH1A1LMNACHRM2 | |
| SCHEMBL90586 | 0.72 | CHRM2 (0.44) | OPRK1MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL7484764 | 0.71 | LMNA (0.56) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL16448458 | 0.71 | OPRM1 (0.50) | OPRM1OPRD1OPRK1OPRL1MEN1 | |
| SCHEMBL8672898 | 0.71 | OPRM1 (0.54) | OPRM1OPRD1OPRK1OPRL1CYP19A1 | |
| SCHEMBL7486355 | 0.70 | OPRM1 (0.44) | OPRM1OPRD1OPRK1OPRL1CYP19A1 | |
| SCHEMBL5666369 | 0.70 | IDO1 (0.38) | IDO1TDO2ALDH1A1CHRM2CHRM4 | |
| SCHEMBL2911607 | 0.70 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228065-A1 | (INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Wyeth (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6245799-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORP | 2001-06-12 | — | — | US | disclosed |
| WO-2001034598-A1 | [(INDOL-3-YL)-CYCLOALKYL]-3-SUBSTITUTED AZETIDINES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WYETH (US) | 2001-05-17 | — | — | WO | disclosed |