Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | HTR2A | P28223 | 2/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 3/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478833 | 1.00 | SLC6A4 (0.57) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| Formic Acid SCHEMBL27577042 | 0.82 | OPRM1 (0.61) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL5787906 | 0.81 | HTR2A (0.64) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL5786565 | 0.81 | HTR2A (0.64) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL5786564 | 0.81 | HTR2A (0.64) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL7484043 | 0.81 | SLC6A4 (0.65) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL7479378 | 0.81 | SLC6A4 (0.65) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL5793597 | 0.80 | SLC6A4 (0.56) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL2781509 | 0.80 | HTR2C (0.62) | SLC6A4HTR1AHTR2ADRD1SLC6A2 | |
| SCHEMBL6342293 | 0.80 | HSD11B1 (0.58) | SLC6A4HTR1AHTR2ADRD1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1068184-B1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | WYETH CORP (US) | 2002-09-04 | — | — | EP | disclosed |
| EP-1068184-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6110956-A | ANTIDEPRESSANTS TREATING DISORDERS OF THE SEROTONIN-AFFECTED NEUROLOGICAL SYSTEMS | AMERICAN HOME PRODUCTS CORP. (US) | 2000-08-29 | — | — | US | disclosed |
| WO-1999051576-A1 | N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |