Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.51 |
| ▸ | CCR9 | P51686 | 4/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | UQCRB | P14927 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686846 | 0.82 | CYP2C19 (0.51) | ALDH1A1KDM4ELMNASCN9ACYP2C19 | |
| SCHEMBL8056340 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KDM4ELMNAHSD17B2CCR9 | |
| SCHEMBL8058999 | 0.78 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNACCR9CYP2C19 | |
| SCHEMBL7838659 | 0.77 | ALDH1A1 (0.55) | ALDH1A1KDM4ELMNAHSD17B2CCR9 | |
| SCHEMBL7486731 | 0.76 | EDNRA (0.56) | ALDH1A1KDM4ELMNACCR9CYP2C19 | |
| SCHEMBL16863131 | 0.76 | POLB (0.67) | ALDH1A1KDM4ELMNAHSD17B2CCR9 | |
| SCHEMBL14098841 | 0.72 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNAHSD17B2CCR9 | |
| SCHEMBL18354995 | 0.72 | KDM4E (1.00) | ALDH1A1KDM4ELMNAMEN1KMT2A | |
| SCHEMBL16863133 | 0.72 | KDM4E (0.54) | ALDH1A1KDM4ELMNAHSD17B2CCR9 | |
| SCHEMBL4103668 | 0.72 | MEN1 (0.55) | ALDH1A1KDM4ELMNAMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959072-B1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO (JP) | 2002-09-25 | — | — | EP | disclosed |
| EP-0959072-A1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1999-11-24 | — | — | EP | disclosed |
| US-5739333-A | 4-SULFONAMIDO-6-ARYLOXY OR -AMINOALKYLENEOXY,-AMINO, OR -THIOPYRIMIDINES; ENDOLTHELIN ANTAGONISTS; HYPOTENSIVE AND ULCER AGENTS; ASTHMA; RAYNAUD DISEASE; CARDIOVASCULAR DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| US-5728706-A | ENDOTHELIN ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0658548-B1 | Benzenesulfonamide derivative and process for preparing thereof | TANABE SEIYAKU CO (JP) | 1997-11-19 | — | — | EP | disclosed |
| US-5589478-A | ENDOTHELIN ANTAGONISTS | TANABE SEIYAKU CO., LTD. (JP) | 1996-12-31 | — | — | US | disclosed |
| EP-0743307-A1 | Sulfonamide derivative and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1996-11-20 | — | — | EP | disclosed |
| EP-0658548-A1 | Benzenesulfonamide derivative and process for preparing thereof | TANABE SEIYAKU CO., LTD. (JP) | 1995-06-21 | — | — | EP | disclosed |