Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25442187 | 0.82 | CYP2C19 (0.76) | CYP2C19ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL7486509 | 0.82 | ALDH1A1 (0.61) | CYP2C19ALDH1A1KDM4ELMNAMAPT | |
| Sulfamonomethoxine SCHEMBL28223172 | 0.76 | CYP2C19 (0.86) | CYP2C19ALDH1A1KDM4ELMNANPSR1 | |
| SCHEMBL2270981 | 0.74 | NPC1 (0.65) | ALDH1A1LMNASMN1; SMN2SCN9A | |
| SCHEMBL14057177 | 0.74 | CCR2 (0.49) | KITCCR2ALDH1A1PGRLMNA | |
| SCHEMBL11977002 | 0.74 | KDM4E (0.70) | CYP2C19ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4103668 | 0.73 | MEN1 (0.55) | KITALDH1A1PGRKDM4ELMNA | |
| SCHEMBL26758662 | 0.72 | ALDH1A1 (0.69) | ALDH1A1KDM4ELMNAPOLBMAPT | |
| SCHEMBL31246327 | 0.72 | CYP2C19 (0.60) | CYP2C19ALDH1A1LMNANPSR1SMN1; SMN2 | |
| SCHEMBL22581664 | 0.71 | DEGS1 (0.57) | ALDH1A1KDM4ELMNASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517890-B1 | CATIONICALLY SUBSTITUTED DIPHENYL AZETIDINONES, METHOD FOR THEIR PRODUCTION, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-07-16 | — | — | EP | claimed |
| US-8476275-B2 | N-[piperazinyl hetaryl]arylsufonamide compounds with affinity for the dopamine D3 receptor | ABBOTT GMBH & CO. KG (DE) | 2013-07-02 | — | — | US | disclosed |
| CN-1805937-B | N-[(piperazinyl)hetaryl]arylsulfonamide compounds with affinity for the dopamine D3 receptor. | ABBOTT GMBH & CO KG | 2012-07-11 | — | — | CN | disclosed |
| US-20110294817-A1 | N-[PIPERAZINYL HETARYL]ARYLSUFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-12-01 | — | — | US | disclosed |
| EP-1613596-B1 | N-[(PIPERAZINYL)HETARYL]ARYLSULFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO KG (DE) | 2008-03-12 | — | — | EP | disclosed |
| US-7320979-B2 | N-[(piperazinyl)hetaryl]arylsulfonamide compounds | ABBOTT GMBH & CO. KG. (DE) | 2008-01-22 | — | — | US | disclosed |
| US-20070054918-A1 | N-[(piperazinyl)hetary]arylsulfonamide compounds with affinity for the dopamine d3 receptor | ABBOTT GMBH & CO. KG (DE) | 2007-03-08 | — | — | US | disclosed |
| US-20060160809-A1 | N-[(piperazinyl)hetaryl]arylsulfonamide compounds | ABBOTT GMBH & CO. KG. | 2006-07-20 | — | — | US | disclosed |
| CN-1805937-A | N-[(piperazinyl)hetaryl]arylsulfonamide compounds with affinity for the dopamine D3 receptor. | BRAJE WILFRIED (DE) | 2006-07-19 | — | — | CN | disclosed |
| EP-1613596-A1 | N-[(PIPERAZINYL)HETARYL]ARYLSULFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004089905-A1 | N-[(PIPERAZINYL)HETARYL]ARYLSULFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204422-A1 | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds | ABBOTT GMBH & CO. KG. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204422-A1 | N-[(Piperazinyl)hetaryl]arylsulfonamide compounds | CBR1, CBR3, CNR2 | CYP2C19 173/4885KMO 1598/4885KIT 4290/4885 |
| US-20110294817-A1 | N-[PIPERAZINYL HETARYL]ARYLSUFONAMIDE COMPOUNDS WITH AFFINITY FOR THE DOPAMINE D3 RECEPTOR | DRD2, DRD3, TACR1 | CYP2C19 474/4885KMO 1421/4885KIT 4305/4885 |
| US-20070054918-A1 | N-[(piperazinyl)hetary]arylsulfonamide compounds with affinity for the dopamine d3 receptor | PTGDR, TACR1, TACR2 | CYP2C19 632/4885KMO 961/4885KIT 4321/4885 |
| US-20060160809-A1 | N-[(piperazinyl)hetaryl]arylsulfonamide compounds | CBR3, CNR2, CNR1 | CYP2C19 472/4885KMO 929/4885KIT 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.