Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7487717 | 0.91 | F10 (0.51) | GRM2SMN1; SMN2SIGMAR1TMEM97F10 | |
| SCHEMBL7484050 | 0.91 | CCR3 (0.49) | SIGMAR1F10 | |
| SCHEMBL7486541 | 0.89 | SIGMAR1 (0.55) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL9678366 | 0.86 | GRM2 (0.67) | GRM2SIGMAR1TMEM97HTR1A | |
| SCHEMBL8799241 | 0.84 | SIGMAR1 (0.51) | GRM2SIGMAR1F10 | |
| SCHEMBL8799320 | 0.84 | SIGMAR1 (0.51) | GRM2SIGMAR1F10 | |
| SCHEMBL9086619 | 0.84 | SIGMAR1 (0.51) | GRM2SIGMAR1F10 | |
| SCHEMBL7481896 | 0.84 | GRM2 (0.58) | GRM2SIGMAR1HTR1A | |
| SCHEMBL9677541 | 0.81 | GRM2 (0.57) | GRM2SIGMAR1TMEM97HTR1A | |
| SCHEMBL9677253 | 0.79 | GRM2 (0.57) | GRM2SIGMAR1TMEM97HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | claimed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | claimed |
| EP-0763535-B1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GMBH (DE) | 2002-11-27 | — | — | EP | disclosed |
| EP-0763535-A1 | Piperidinylmethyloxazolidin-2-one derivatives, their preparation and their use as pharmacological active CNS compounds | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |