Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7529065 | 1.00 | GRM2 (0.57) | GRM2SLC6A2SLC6A4ALDH1A1SIGMAR1 | |
| SCHEMBL9678366 | 0.92 | GRM2 (0.67) | GRM2SLC6A2SLC6A4SIGMAR1HTR1A | |
| SCHEMBL7487787 | 0.90 | SIGMAR1 (0.50) | GRM2SLC6A2SLC6A4ALDH1A1SIGMAR1 | |
| SCHEMBL9844385 | 0.89 | SLC6A2 (0.58) | GRM2SLC6A2SLC6A4ALDH1A1CCR3 | |
| SCHEMBL9676204 | 0.89 | GRM2 (0.57) | GRM2ALDH1A1SIGMAR1HTR1A | |
| SCHEMBL9677541 | 0.89 | GRM2 (0.57) | GRM2SIGMAR1HTR1ATMEM97 | |
| SCHEMBL9677266 | 0.89 | GRM2 (0.54) | GRM2SLC6A2SLC6A4ALDH1A1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9679291 | 0.88 | GRM2 (0.56) | GRM2ALDH1A1SIGMAR1HTR1A | |
| SCHEMBL9678853 | 0.86 | SIGMAR1 (0.65) | GRM2SIGMAR1 | |
| SCHEMBL7481896 | 0.86 | GRM2 (0.58) | GRM2SIGMAR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300272-B1 | OXAZOLIDINONES | MERCK PATENT GmbH (DE) | 1992-09-16 | — | — | EP | disclosed |
| US-4970217-A | NEUROLEPTIC | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-11-13 | — | — | US | disclosed |
| EP-0300272-A1 | Oxazolidinones | MERCK PATENT GmbH (DE) | 1989-01-25 | — | — | EP | disclosed |