Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.38 |
| ▸ | KCNN3 | Q9UGI6 | 5/20 | 0.36 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.36 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443544 | 0.88 | AGTR1 (0.41) | PDE10AAGTR1GSK3BKCNN3KCNN1 | |
| SCHEMBL7433723 | 0.87 | AGTR1 (0.46) | AGTR1KCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL7445211 | 0.87 | AGTR1 (0.52) | AGTR1GSK3BKCNN3KCNN1KCNN2 | |
| SCHEMBL7438339 | 0.86 | AGTR1 (0.44) | PDE10AAGTR1KCNN3KCNN1KCNN2 | |
| SCHEMBL7438046 | 0.83 | PDE10A (0.47) | PDE10AAGTR1GSK3BKCNN3KCNN1 | |
| SCHEMBL7487675 | 0.80 | DPP4 (0.36) | DPP4 | |
| SCHEMBL7439807 | 0.78 | GSK3B (0.49) | AGTR1GSK3BCDK2 | |
| SCHEMBL7434200 | 0.78 | KMT2A (0.40) | AGTR1GSK3BCDK2 | |
| SCHEMBL7438615 | 0.78 | AGTR1 (0.42) | AGTR1GSK3BCDK2 | |
| SCHEMBL7436086 | 0.78 | GSK3B (0.41) | AGTR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |