Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 16/20 | 0.46 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496564 | 0.88 | MAPT (0.42) | CCR2KDM4EALDH1A1GAATSHR | |
| SCHEMBL7498811 | 0.87 | CCR2 (0.49) | CCR2SERPINE1KDM4EALDH1A1LMNA | |
| SCHEMBL7137416 | 0.84 | CCR2 (0.45) | CCR2ABCB11 | |
| SCHEMBL7466632 | 0.81 | CCR2 (0.45) | CCR2ABCB11 | |
| SCHEMBL7496568 | 0.76 | MAPT (0.44) | CCR2KDM4EALDH1A1LMNAGAA | |
| SCHEMBL7470926 | 0.73 | CCR2 (0.44) | CCR2ABCB11 | |
| SCHEMBL7473359 | 0.73 | CCR2 (0.44) | CCR2ABCB11 | |
| SCHEMBL7467118 | 0.73 | CCR2 (0.50) | CCR2ABCB11 | |
| SCHEMBL8389272 | 0.72 | CCR2 (0.54) | CCR2ABCB11 | |
| SCHEMBL7465994 | 0.72 | PLA2G4A (0.46) | CCR2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242075-A4 | INDOLE COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| EP-1242075-A2 | INDOLE COMPOUNDS | SmithKline Beecham Corporation (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001030752-A2 | INDOLE COMPOUNDS FOR TREATING BACTERIAL INFECTIONS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-03 | — | — | WO | disclosed |