Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CSNK1A1L | Q8N752 | 1/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11087266 | 1.00 | PTGS2 (0.64) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL11090108 | 0.91 | PTGS1 (0.62) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL213705 | 0.88 | PTGS2 (0.70) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL5698511 | 0.88 | PTGS2 (0.70) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL11082923 | 0.87 | BRAF (0.57) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL7085273 | 0.86 | PTGS2 (0.68) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL7480312 | 0.86 | PTGS2 (0.64) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL7090719 | 0.86 | PTGS2 (0.64) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL7085602 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1ALOX5MAPK11MAPK14 | |
| SCHEMBL11083042 | 0.81 | BRAF (0.49) | PTGS2PTGS1ALOX5MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772601-B1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2002-09-18 | — | — | EP | disclosed |
| US-6426360-B1 | ANTIARTHRITIC AGENTS | G D SEARLE & CO. | 2002-07-30 | — | — | US | disclosed |
| EP-1211244-A2 | 4,5-substitued imidazolyl compounds for the treatment of inflammation | G.D. Searle & Co. (US) | 2002-06-05 | — | — | EP | disclosed |
| US-5620999-A | ANTIARTHRITIC, ANALGESIC AND ANTIPYRATIC AGENT | G.D. SEARLE & CO. | 1997-04-15 | — | — | US | disclosed |
| WO-1996003387-A1 | 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-02-08 | — | — | WO | disclosed |