Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.49 |
| ▸ | PPIA | P62937 | 4/20 | 0.48 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | PPIF | P30405 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7551257 | 0.95 | SGMS2 (0.53) | SGMS2PPIACXCR1CXCR2CHEK1 | |
| SCHEMBL7552006 | 0.91 | CXCR2 (0.57) | PPIACXCR1CXCR2BRD4KMT2A | |
| SCHEMBL7488381 | 0.86 | SGMS2 (0.46) | SGMS2PPIACHEK1LRRK2CYP11B1 | |
| SCHEMBL7514780 | 0.84 | CXCR1 (0.56) | SGMS2PPIACXCR1CXCR2LRRK2 | |
| SCHEMBL7492629 | 0.84 | CXCR2 (0.62) | SGMS2PPIACXCR1CXCR2BRD4 | |
| SCHEMBL7484203 | 0.77 | PPIA (0.59) | PPIACXCR1CXCR2CYP11B1CYP11B2 | |
| SCHEMBL3707120 | 0.74 | CXCR1 (0.67) | CXCR1CXCR2MEN1KMT2AKDM4E | |
| SCHEMBL7515957 | 0.74 | CXCR2 (0.58) | SGMS2PPIACXCR1CXCR2MEN1 | |
| SCHEMBL7549892 | 0.73 | KMT2A (0.57) | PPIACXCR1CXCR2PPIFMEN1 | |
| SCHEMBL38660891 | 0.69 | MAPT (0.60) | SGMS2CYP11B1CYP11B2BRD4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |