Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.46 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7488374 | 0.86 | SGMS2 (0.49) | SGMS2PPIACYP11B1CYP11B2LRRK2 | |
| SCHEMBL7551257 | 0.81 | SGMS2 (0.53) | SGMS2PPIACYP11B1CYP11B2LRRK2 | |
| SCHEMBL7552006 | 0.77 | CXCR2 (0.57) | PPIAALOX15BRD4 | |
| SCHEMBL7514780 | 0.70 | CXCR1 (0.56) | SGMS2PPIALRRK2SMN1; SMN2BRD4 | |
| SCHEMBL7492629 | 0.69 | CXCR2 (0.62) | SGMS2PPIACYP19A1BRD4 | |
| SCHEMBL38660891 | 0.67 | MAPT (0.60) | SGMS2CYP11B1CYP11B2HTTKDM1A | |
| Urea SCHEMBL7511030 | 0.66 | PPIA (0.39) | SGMS2PPIACYP11B1CYP11B2LRRK2 | |
| SCHEMBL31014109 | 0.65 | PARP10 (0.45) | PPIACYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL17629916 | 0.64 | CYP11B1 (0.50) | SGMS2CYP11B1CYP11B2LRRK2CYP19A1 | |
| SCHEMBL17630139 | 0.64 | CYP11B1 (0.50) | SGMS2CYP11B1CYP11B2LRRK2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |