Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 3/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 3/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677272 | 0.84 | FABP3 (0.38) | FABP3FABP4FABP5LMNAHTR1D | |
| SCHEMBL7479694 | 0.81 | LMNA (0.44) | LMNAHTR1DTRPA1PTGS1CACNA1C | |
| SCHEMBL5050256 | 0.79 | FABP3 (0.41) | FABP3FABP4FABP5LMNAHTR1D | |
| SCHEMBL10822928 | 0.79 | GABRA1 (0.39) | LMNAGABRA1ALDH1A1GAAHTT | |
| SCHEMBL7484699 | 0.79 | GABRA1 (0.39) | GABRA1GABRB2 | |
| SCHEMBL27601762 | 0.78 | IDO1 (0.38) | FABP3FABP4FABP5LMNAHTR1D | |
| SCHEMBL9686320 | 0.76 | ACE2 (0.42) | FABP3FABP4FABP5LMNAGABRA1 | |
| SCHEMBL22356520 | 0.76 | FABP3 (0.38) | FABP3FABP4FABP5LMNAHTR1D | |
| SCHEMBL21145862 | 0.76 | FABP3 (0.38) | FABP3FABP4FABP5LMNAHTR1D | |
| SCHEMBL20739967 | 0.74 | GABRA1 (0.41) | LMNAGABRA1GABRB2PTGS1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |