SCHEMBL7488458

SCHEMBL7488458

NC(CC(=O)O)c1nn[nH]n1

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.51
NAALAD2 Q9Y3Q0 3/20 0.47
APEX1 P27695 1/20 0.38
DDAH1 O94760 1/20 0.38
GRM1 Q13255 1/20 0.37
KDM6B O15054 1/20 0.36
KDM4A O75164 1/20 0.36
KDM5A P29375 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GRIA1 P42261 1/20 0.35
GRIA2 P42262 1/20 0.35
GRIA3 P42263 1/20 0.35
GRIA4 P48058 1/20 0.35
MMEL1 Q495T6 1/20 0.35
ALDH1A1 P00352 1/20 0.34
RECQL P46063 1/20 0.34
PIN1 Q13526 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9985442 0.85 CYP1A2 (0.47) CYP1A2NAALAD2DDAH1GRM1KDM6B
SCHEMBL12799249 0.79 NAALAD2 (0.49) CYP1A2NAALAD2APEX1KDM6BKDM4A
SCHEMBL12799252 0.78 NAALAD2 (0.47) CYP1A2NAALAD2APEX1GRM1L3MBTL1
SCHEMBL19996040 0.75 NAALAD2 (0.45) CYP1A2NAALAD2APEX1L3MBTL1MMEL1
SCHEMBL13319916 0.75 NAALAD2 (0.44) CYP1A2NAALAD2GRM1KDM6BKDM4A
Trifluoroacetic Acid SCHEMBL18762550 0.72 CYP1A2 (0.46) CYP1A2NAALAD2DDAH1GRM1KDM6B
Trifluoroacetic Acid SCHEMBL18762578 0.70 CYP1A2 (0.43) CYP1A2NAALAD2DDAH1GRM1KDM6B
SCHEMBL18774997 0.69 CYP1A2 (0.50) CYP1A2NAALAD2DDAH1L3MBTL1ALDH1A1
SCHEMBL23646039 0.69 NAALAD2 (0.40) CYP1A2NAALAD2DDAH1GRM1KDM6B
SCHEMBL8893948 0.68 KDM4E (0.32) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761668-B1 Non-classical antifolates UNIV PRINCETON (US) 2002-01-30 EP disclosed
US-5786358-A INHIBITORS OF GLYCINAMIDE RIBONUCLEOTIDE FORMYL TRANSFERASE THE TRUSTEES OF PRINCETON UNIVERSITY (US) 1998-07-28 US disclosed
EP-0761668-A2 Non-classical antifolates THE TRUSTEES OF PRINCETON UNIVERSITY (US) 1997-03-12 EP disclosed