Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8341038 | 1.00 | KDM4E (0.32) | KDM4EALDH1A1POLBAPOBEC3GTDP1 | |
| SCHEMBL1641200 | 0.82 | TDP1 (0.34) | KDM4EALDH1A1POLBAPOBEC3GTDP1 | |
| SCHEMBL3787466 | 0.77 | ALDH1A1 (0.35) | KDM4EALDH1A1POLBAPOBEC3GTDP1 | |
| SCHEMBL4122580 | 0.74 | APEX1 (0.35) | KDM4EALDH1A1POLBAPOBEC3GTDP1 | |
| SCHEMBL10231795 | 0.74 | GRM1 (0.34) | KDM4ELMNA | |
| SCHEMBL9388195 | 0.71 | — | — | |
| SCHEMBL14909327 | 0.68 | TAAR1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL729364 | 0.68 | TAAR1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL7413806 | 0.68 | TAAR1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL7488458 | 0.68 | CYP1A2 (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2850095-A1 | PEPTIDE AND PEPTIDOMIMETIC INHIBITORS | RA Pharmaceuticals, Inc. (US) | 2015-03-25 | — | — | EP | claimed |
| WO-2013172954-A1 | PEPTIDE AND PEPTIDOMIMETIC INHIBITORS | RA PHARMACEUTICALS, INC (US) | 2013-11-21 | — | — | WO | claimed |
| US-5658885-A | OLIGOPEPTIDES; ANTICOAGULANTS; ENZYME INHIBITORS; THROMBIN | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-08-19 | — | — | US | disclosed |