Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492187 | 0.85 | KDM4E (0.35) | ALDH1A1L3MBTL1 | |
| SCHEMBL7487734 | 0.81 | HCAR2 (0.34) | EGFRMAPK14AURKAPARP1 | |
| SCHEMBL7496587 | 0.80 | MET (0.34) | — | |
| SCHEMBL7495751 | 0.78 | CCNB2 (0.34) | ALDH1A1L3MBTL1EGFR | |
| SCHEMBL7491129 | 0.75 | KDM4E (0.35) | ALDH1A1 | |
| SCHEMBL7486783 | 0.75 | KMT2A (0.39) | ALDH1A1L3MBTL1GSK3BFEN1AURKA | |
| SCHEMBL6092462 | 0.72 | GSK3B (0.49) | PRKCBGSK3BAURKA | |
| SCHEMBL6092457 | 0.72 | GSK3B (0.49) | PRKCBGSK3BAURKA | |
| SCHEMBL6088918 | 0.71 | CHEK1 (0.58) | ALDH1A1L3MBTL1GSK3B | |
| SCHEMBL6088922 | 0.71 | CHEK1 (0.58) | ALDH1A1L3MBTL1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |