Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7492943 | 0.82 | PDE3B (0.38) | KMT2AKDM4EERN1ALDH1A1MTNR1A | |
| SCHEMBL29955300 | 0.79 | KMT2A (0.44) | KMT2AKDM4EERN1AURKAPARP1 | |
| SCHEMBL7487734 | 0.76 | HCAR2 (0.34) | KDM4EAURKAPARP1ADORA2AADORA1 | |
| SCHEMBL7488483 | 0.75 | ALDH1A1 (0.33) | AURKAPARP1FEN1ALDH1A1GSK3B | |
| SCHEMBL6015974 | 0.73 | CYP1A2 (0.38) | KMT2AKDM4EERN1AURKAPARP1 | |
| SCHEMBL1714222 | 0.70 | KMT2A (0.47) | KMT2AKDM4EERN1AURKAPARP1 | |
| SCHEMBL2345339 | 0.70 | KMT2A (0.47) | KMT2AKDM4EERN1AURKAPARP1 | |
| SCHEMBL7706342 | 0.70 | RHEB (0.38) | KMT2AKDM4EALDH1A1CDC7ROCK2 | |
| SCHEMBL8326415 | 0.68 | RIPK1 (0.40) | KMT2AAURKAPARP1FEN1MAPT | |
| SCHEMBL12024540 | 0.67 | KDM4E (0.44) | KMT2AKDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |