Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7478690 | 0.81 | MAPT (0.49) | MAPTMEN1KMT2AGAAHTT | |
| SCHEMBL1844417 | 0.70 | MAPT (0.65) | MAPTHTTALDH1A1NPSR1SIRT6 | |
| SCHEMBL4971357 | 0.68 | MAPT (0.48) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL30344994 | 0.68 | MAPT (0.58) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL23997214 | 0.68 | MAPT (0.58) | MAPTMEN1KMT2AL3MBTL1GAA | |
| SCHEMBL1845533 | 0.68 | MAPT (0.74) | MAPTGAAHTTALDH1A1NPSR1 | |
| SCHEMBL31066783 | 0.67 | SIRT6 (0.43) | MAPTKMT2AL3MBTL1HTTALDH1A1 | |
| SCHEMBL21291603 | 0.67 | SIRT6 (0.43) | MAPTKMT2AL3MBTL1HTTALDH1A1 | |
| SCHEMBL22712825 | 0.67 | SIRT6 (0.60) | MAPTMEN1KMT2AL3MBTL1HTT | |
| SCHEMBL6474847 | 0.67 | HTR6 (0.58) | MAPTMEN1KMT2AL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865281-B1 | NAPHTHYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS ANTICOAGULANTS | BERLEX LAB (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5849759-A | Naphthyl-substituted benzimidazole derivatives as anti-coagulants | BERLEX LABORATORIES, INC. (US) | 1998-12-15 | — | — | US | disclosed |