Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136935 | 0.84 | NPC1 (0.50) | HTTALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL787034 | 0.81 | KDM4E (0.67) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5561766 | 0.79 | KDM4E (0.65) | HTTALDH1A1KDM4ESMN1; SMN2CYP1A2 | |
| SCHEMBL13771316 | 0.79 | TAAR1 (0.54) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL5560596 | 0.77 | POLB (0.65) | HTTALDH1A1KDM4ESMN1; SMN2POLB | |
| SCHEMBL254573 | 0.73 | SMN1; SMN2 (0.72) | HTTALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL3690777 | 0.72 | KDM4E (0.49) | ALDH1A1KDM4ESMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL28661867 | 0.72 | SMN1; SMN2 (0.65) | HTTALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL19681498 | 0.71 | MAOB (0.60) | HTTHRH3 | |
| SCHEMBL18615761 | 0.71 | NAAA (0.54) | KDM4EEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538384-A4 | OXAMIDES | SMITHKLINE BEECHAM CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0538384-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1992000968-A1 | OXAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-01-23 | — | — | WO | disclosed |